Product Description
DESCRIPTION:
Pantoprazole Sodium is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[(3, 4-dimethoxy-2-pyridinyl) methyl) sulfinyl]-1H benzimidazole, a compound that inhibits gastric acid secretion.
PACKING:
40mg vial and 10 ml sodium chloride ampoule
COMPOSITION:
Part I each vial contains:
| Pantoprazole Sodium equivalent to Pantoprazole | USP | 40 mg |
Part II each ampoule contains:
| Sodium Chloride | B.P. | 0.9 %w/v |
| Water for injection | B.P. | q.s. |
MECHANISM OF ACTION:
Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested.
Sodium is the major cation of extracellular fluid and functions principally in the control of water distribution, fluid and electrolyte balance and osmotic pressure of body fluids. Chloride, the major extracellular anion, closely follows the physiological disposition of the sodium cation in maintenance of acid-base balance, isotonicity and electrodynamic characteristics of cells.
INDICATIONS:
Indicated for the treatment of moderate and severe reflux esophagitis.
DOSAGE AND ADMINISTRATION:
As directed by the physician. For slow IV use only.
DIRECTION FOR RECONSTITUTION:
The content of the vial needs to be reconstituted with 10 ml of Sodium Chloride Injection BP 0.9% w/v before injection.
This freshly prepared solution should be administered intravenously over 2 to 15 minutes, either as a slow injection or it may be further diluted with 100 ml of sodium chloride injection BP 0.9 % w/v or 5% glucose injection and administered as a short term infusion. The reconstituted solution must be used within 12 hours of preparation.
SIDE EFFECTS:
Headache, diarrhoea, abdominal pain, flatulence, constipation, allergic reactions such as skin rash and pruritus may occur.
CONTRAINDICATIONS:
Contraindicated in patients with known hypersensitivity to the formulation.
STORAGE:
Store in a cool place, below 25℃. Protect from light.
PRESENTATION:
One 40 mg vial with 10 ml Sodium Chloride ampoule
BARCODE:
MANUFACTURED BY:
TORQUE PHARMACEUTICALS PVT. LTD.
ISSAPUR, P.O. DAPPAR- 140 506.
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