Product Description
Description: Torque’s Glimtor MV1 Tablets contains Glimepiride, a sulphonylurea antihyperglycaemic agent acts mainly by stimulating insulin release from pancreatic beta cells, Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose and Voglibose, an alpha glucosidase inhibitor.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition: Each uncoated bilayered tablet contains:
Glimepride IP 1 mg
Metformin Hydrochloride IP 500 mg
(As extended release)
Voglibose IP 0.2 mg
Excipients q.s.
Mechanism of Action: Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta-cells. It binds to the sulphonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Voglibose is an alpha glucosidase inhibitor which reduces intestinal absorption of starch, dextrin, and disaccharides by inhibiting the action of α-glucosidase in the intestinal brush border. Inhibition of this enzyme catalyzes the decomposition of disaccharides into monosaccharides and slows the digestion and absorption of carbohydrates; the postprandial rise in plasma glucose is blunted in both normal and diabetic subjects resulting in improvement of post prandial hyperglycemia and various disorders caused by hyperglycemia.
Indications: Torque’s Glimtor MV1 is indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and single agent does not result in adequate glycemic control.
Dosage: As directed by the physician.
Storage: Store at a temperature not exceeding 30ºC, protect from light & moisture.
Presentation: 10 x 15
Side effects: The following adverse reactions may occur:
Lactic Acidosis
Taste Disturbance
Nausea, Vomiting, Diarrhoea, Abdominal Pain, Flatulence, Loss of Appetite
Upper respiratory tract infection
Anaemia
Hypo-Glycaemia
Hypo-Aesthesia
Headache, Dizziness
Arthralgia, Back Pain
Haematuria
Erectile Dysfunction
Contraindications:
Torque’s Glimtor MV1 is contraindicated in patients with:
Known hypersensitivity to metformin, glimepiride, voglibose or any of the components of this product.
Severe renal impairment
Acute or chronic metabolic acidosis, including diabetic ketoacidosis and lactic acidosis
Diabetic pre-coma
Patients with established NYHA class III or IV heart failure
Acute or chronic disease which may cause tissue hypoxia such as cardiac or respiratory
failure, recent myocardial infarction, shock
Hepatic insufficiency, acute alcohol intoxication, alcoholism
Acute conditions with the potential to alter renal function such as:
– Dehydration
– Severe infection
– Shock
– Intravascular administration of iodinated contrast agents
Lactation
Drug Interactions:
Alcohol
NSAIDs
ACE Inhibitors
Angiotensin II Receptor Antagonists
Diuretics
Verapamil
Rifampicin
Cimetidine, Dolutegravir, Ranolazine, Trimethoprime,
Isavuconazole, Fluconazole
Vandetanib, Crizotinib, Olaparib
Thyroid Stimulating Agents, Glucocorticoids
Anabolic Steroids and Male Sex Hormones
Gemfibrozil
