Product Description
Description: Kofnil Expectorant Syrup contains Salbutamol – bronchodilator, bromhexine – mucolytic and expectorant, Guaiphenesin – expectorant and menthol – cooling agent is used in the treatment of productive cough asthma bronchitis, acute bronchitis and acute exacerbation of chronic bronchitis.
Pharmaceutical Dosage Form: Syrup
Route of Administration: Oral
Composition:
Each 10 ml contains:
Salbutamol Sulphate I.P.
equivalent to Salbutamol I.P. 2 mg
Bromhexine Hydrochloride I.P. 4 mg
Guaiphenesin I.P. 100 mg
Menthol I.P. 1 mg
In a soothing Glycerine & syrup base q.s.
Colour: Sunset Yellow FCF
Mechanism of Action: Salbutamol is a β2-adreneceptor agonist binds to the β2 receptor, which activates adenyl cyclase, resulting in the conversion of cyclic AMP. Cyclic AMP then triggers a cascade of intracellular events that culminate in the inhibition of the contraction of bronchial smooth muscle, thereby promoting smooth muscle relaxation and bronchodilation. Bromhexine is a mucolytic, helps in enhancing the production of serous mucus in the respiratory tract and helps in the production of thinner and less viscous phlegm. This produces a secretomotoric effect by helping the cilia in expectoring the phlegm out of the lungs. Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. It is used for relief of wet cough and chest congestion due to the common cold. Menthol triggers cooling sensation in the upper airways and provides relief from nasal congestion and dyspnea in patients with chronic obstructive pulmonary disease.
Indications: Kofnil Expectorant Syrup is indicated for clinical relief of cough associated with bronchitis, bronchial asthma, emphysema and other bronchopulmonary disorders where bronchospasm, mucous plugging and problems of expectoration co-exist.
Dosage: As directed by the physician.
Storage: Store below 25°C. Protect from light. Transient temperature upto 40°C allowed.
Presentation: 100 ml
Side effects:
Tremor
Tension
Restlessness
Rapid heartbeat
Headache
Hypersensitivity
Rash/ urticarial/ pruritus
Bronchospasm
Nausea
Vomiting
Diarrhea
Abdominal pain
Contraindications: Kofnil Expectorant Syrup is contraindicated in patients with a history of hypersensitivity to the drug or any excipients from the dosage form.
Drug Interactions: Here are some notable drug interactions with this medication:
Anaesthetic agents
Guanethidine
Reserpine
Methyldopa
Tricyclic antidepressants
Non-selective beta-blocking drugs
