KOFNIL SYRUP

Each 5 ml contains:

DESCRIPTION: KOFNIL SYRUP is anti-tussivemedication primarily used to treat dry cough, stuffy nose, sinus, and ear symptoms caused by the common cold and flu. Dextromethorphan HBrcontains an anti-tussive (relieve cough) medication primarily used to treat dry cough. A cough is a reflex action that helps clear any foreign irritant or mucus in the throat. Phenylephrine is used to relieve stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis). Chlorpheniramine relieves red, itchy, watery eyes, sneezing, itchy nose or throat, and runny nose caused by allergies, hay fever, and the common cold. Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery. Chlorpheniramine is in a class of medications called antihistamines.  

MECHANISM OF ACTION:

Dextromethorphan HBrcrosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.

Phenylephrine works by directly stimulating alpha-1 adrenergic receptors in the arteries causing vasoconstriction (narrowing of the blood vessels). This reduces nasal congestion by preventing fluid from draining from the blood vessels into the tissues lining the nasal passages.

Chlorpheniramine maleate works by blocking a particular natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and a runny nose.