Product Description
Description: Rosvamac 10 Tablets contain Rosuvastatin which is a synthetic lipid-altering agents.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition:
Each film coated tablet contains:
Rosuvastatin Calcium IP
Eq. to Rosuvastatin 10 mg
Excipients q.s.
Colours: Red Oxide of Iron & Titanium Dioxide IP
Mechanism of Action: Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action of Rosuvastatin is the liver, the target organ for cholesterol lowering. Rosuvastatin increases the number of hepatic LDL receptors on the cell-surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles.
Indications: Rosvamac 10 is indicated as adjunctive therapy to diet to reduce elevated total-C, LDL-C, ApoB, non-HDL-C, and TG and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia, Familial Hypercholesterolemia, Hypertriglyceridemia, Primary Dysbetalipoproteinemia, Homozygous Familial Hypercholesterolemia, slow the progression of atherosclerosis, Prevention of Cardiovascular Disease
Dosage: As directed by the physician.
Storage: Store at a temperature not exceeding 30°C, protected from light & moisture.
Presentation: 10X10 Tablets
Side effects:
Headache
Dizziness
Constipation
Nausea
Abdominal
Pain
Myalgia
Asthenia
Contraindications: Rosvamac 10 is contraindicated in patients with hypersensitivity to Rosuvastatin or to any of the excipients, active liver disease, severe renal impairment, myopathy, receiving concomitant ciclosporin, receiving concomitant combination of sofosbuvir/velpatasvir/voxilaprevir, during pregnancy and lactation and childbearing potential not using appropriate contraceptive measures.
Drug Interactions: Rosvamac 10 can cause drug interaction with following drugs:
Transporter protein inhibitors
Ciclosporin
Protease inhibitors
Gemfibrozil and other lipid-lowering products
Ezetimibe
Antacid
Erythromycin
Cytochrome P450 enzymes
