Description: Rosvamac 20 Tablets contain Rosuvastatin which is a synthetic lipid-altering agents. Pharmaceutical Dosage Form: Tablet Route of Administration: Oral Composition:
| Each film coated tablet contains: | ||
| Rosuvastatin Calcium Eq. to Rosuvastatin | IP | 20 mg |
| Excipients | q.s. | |
Mechanism of Action: Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action of Rosuvastatin is the liver, the target organ for cholesterol lowering. Rosuvastatin increases the number of hepatic LDL receptors on the cell-surface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles. Indications: Rosvamac 20 Tablets are indicated as adjunctive therapy to diet to reduce elevated total-C, LDL-C, ApoB, non-HDL-C, and TG and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia, Familial Hypercholesterolemia, Hypertriglyceridemia, Primary Dysbetalipoproteinemia, Homozygous Familial Hypercholesterolemia, slow the progression of atherosclerosis, Prevention of Cardiovascular Disease Dosage: As directed by the physician. Storage: Store at a temperature not exceeding 30°C, protected from light & moisture. Presentation: 20 X 10 Tablets Side effects: Headache Dizziness Constipation Nausea Abdominal Pain Myalgia Asthenia Contraindications: Rosvamac 20 Tablets are contraindicated in patients with hypersensitivity to Rosuvastatin or to any of the excipients, active liver disease, severe renal impairment, myopathy, receiving concomitant ciclosporin, receiving concomitant combination of sofosbuvir/ velpatasvir/ voxilaprevir, during pregnancy and lactation and childbearing potential not using appropriate contraceptive measures. Drug Interactions: Rosvamac 20 Tablets can cause drug interaction with following drugs: Transporter protein inhibitors Ciclosporin Protease inhibitors Gemfibrozil and other lipid-lowering products Ezetimibe Antacid Erythromycin Cytochrome P450 enzymes