Product Description
Description: Teneglee M 500 Tablets contain teneligliptin which is a dipeptidyl peptidase-4 (DPP-4) inhibitor and Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition:
Each uncoated bilayered tablet contains:
Teneligliptin Hydrobromide Hydrate IP
Eq. to Teneligliptin 20 mg
Metformin Hydrochloride IP 500 mg
(in sustained release form)
Excipients q.s.
Colour: Ferric Oxide Yellow USP-NF (in Teneligliptin layer)
Mechanism of Action: The glucagon-like peptide-1 (GLP-1) is secreted from alimentary canal in response to meal that promotes insulin secretion from pancreas and regulates blood sugar post meal by controlling glucagon secretion. Teneligliptin exhibits a hypoglycemic effect by controlling the decomposition of GLP-1 by inhibiting dipeptidyl peptidase-4 (DPP-4) activity and thereby increasing blood concentration of active GLP-1. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Indications: Teneglee M 500 is indicated for the treatment of type 2 Diabetes Mellitus as a monotherapy adjunct to diet and exercise.
Dosage: As directed by the physician.
Storage: Store below 25°C, away from direct sunlight, heat & moisture.
Presentation: 10 X 10 Tablets
Side effects:
Hypoglycemia
Dizziness
Headache
Constipation
Diarrhoea
Abdominal pain
Hepatic steatosis
Rash
Edema
Contraindications: Teneglee M 500 is contraindicated in patients with severe ketosis, diabetic coma or pre-coma, type 1 diabetes, severe trauma, renal failure or acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock, hepatic insufficiency, acute alcohol intoxication and alcoholism (due to the metformin component).
Drug Interactions: Teneglee M 500 can cause drug interaction with following drugs:
Other antidiabetics
Furosemide
Ketoconazole combination
Class IA anti arrhythmic drugs: Quinidine Sulfate Hydrate, Procainamide Hydrochloride Cholestyramine
Class III antiarrhythmic drugs: Amiodarone Hydrochloride, Sotalol Hydrochloride
β-blocking agents
Salicylic acid drugs
Monoamine oxidase inhibitor
Adrenaline
Adrenocortical hormone
Thyroid hormone
