Product Description
Description: Torliptin VM 500 contains Vildagliptin, a member of the islet enhancer class, is a potent and selective DPP-4 inhibitor and Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition: Each film coated tablet contains:
Vildagliptin IP 50 mg
Metformin Hydrochloride IP 500 mg
Excipients q.s.
Mechanism of Action: Vildagliptin results in a rapid and complete inhibition of DPP-4 activity, resulting in increased fasting and postprandial endogenous levels of the incretin hormones GLP1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide). Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Indications: Torliptin VM 500 is indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and single agent does not result in adequate glycemic control.
Dosage: As directed by the physician.
Storage: Store protected from moisture, at a temperature not exceeding 30ºC.
Presentation: 10 x 15
Side effects: The following adverse reactions may occur:
Hypoglycaemia
Tremor
Headache
dizziness
Nausea
Contraindications: Torliptin VM 500 is contraindicated in patients with:
Known hypersensitivity to Vildaglitin, Metformin or any of the components of this product.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis)
Diabetic pre-coma
Severe renal failure (GFR < 30 ml/min)
Acute conditions with the potential to alter renal function, such as:
dehydration
severe infection
shock
intravascular administration of iodinated contrast agents.
Acute or chronic disease which may cause tissue hypoxia, such as:
cardiac or respiratory failure,
recent myocardial infarction,
shock
Hepatic impairment
Acute alcohol intoxication, alcoholism
Breast-feeding
Drug Interactions:
Alcohol
NSAIDs
ACE Inhibitors
Angiotensin II Receptor Antagonists
Diuretics
