Torque's Combitor Tablets

DESCRIPTION: Torque's Combitor Tablets contains Ibuprofen & Paracetamol, which act as anti-inflammatory & analgesics.

PHARMACEUTICAL DOSAGE FORM: Tablets

ROUTE OF ADMINISTRATION: Oral

COMPOSITION:

Each uncoated tablet contains:

Ibuprofen IP                                  400mg

Paracetamol IP                             325mg

Excipients                                     q.s.

MECHANISM OF ACTION: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Paracetamol is an antipyretic (fever reducer) and analgesic (pain reducer).

INDICATIONS: For temporary relief of pain associated with: headache, migraine, backache, period pain, dental pain, muscular pain, dysmenorrhea, cold and flu symptoms, sore throat and fever.

DOSAGE AND ADMINISTRATION: As directed by the Physician.

CONTRAINDICATIONS: This product is contraindicated for use:

• in patients with known hypersensitivity reaction to paracetamol, ibuprofen, other NSAIDs or to any of the excipients.

• in patients who have experienced asthma, urticaria, or allergic-type reactions after taking acetylsalicylic acid or other NSAIDs.

• in patients with active or history of gastrointestinal bleeding or peptic ulceration.

DRUG INTERACTIONS:

• Fluconazole, Voriconazole increases plasma concentration of Ibuprofen.
• Antiplatelet effect of Aspirin possibly reduced by Ibuprofen.
• Excretion of Baclofen, Methotrexate reduced by Ibuprofen.
• Increased risk of nephrotoxicity when ibuprofen given with Tacrolimus.
• Lixisenatide possibly reduces the absorption of Paracetamol
• Ketoconazole advises avoid concomitant use with Paracetamol.
• Carbamazepine possibly accelerates metabolism of Paracetamol.
• Colestyramine reduces absorption of Paracetamol.
• Anticoagulant effect of coumarins possibly enhanced by prolonged regular use of Paracetamol.
• Metoclopramide increases rate of absorption of Paracetamol.

SIDE EFFECTS: This medication may cause abdominal pain, diarrhea, dyspepsia, nausea, stomach discomfort, vomiting, dizziness, headache, nervousness, rash (including maculopapular type), and pruritus.

PRECAUTIONS & WARNING:

• Bronchospasm may be precipitated in patients suffering from or with a previous history of bronchial asthma.
• Ibuprofen should not be given to patients in whom aspirin and other non-steroidal anti-inflammatory drugs induce the symptoms of asthma, rhinitis or urticaria.
• Overdose of paracetamol may cause liver damage

STORAGE: Store protected from moisture, at a temperatutre below 30°C.

PACKAGING: 10x15 tablets