Product Description
Description: Amtorque 5 Tablets contain amlodipine which is a calcium ion influx inhibitor of the dihydropyridine group.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition: Each uncoated tablet contains:
| Amlodipine Besilate | I.P. | |
| Eq. to Amlodipine | 5mg | |
| Excipients | q.s. |
Mechanism of Action: The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. Amlodipine dilates peripheral arterioles and thus, reduces the total peripheral resistance (afterload) against which the heart works. The mechanism of action of amlodipine also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal’s or variant angina).
Indications: Amtorque 5 is indicated for the treatment of hypertension & angina pectoris, to reduce the risk of fatal coronary heart disease and nonfatal myocardial infarction, stroke, coronary revascularization procedures and the need for hospitalization due to angina in patients with coronary artery disease.
Dosage: As directed by the physician.
Storage: Store protected from light & moisture at a temperature not exceeding 25°C
Presentation: 10X15 Tablets
Side effects:
Somnolence
Dizziness
Headache
Palpitations
Flushing
Abdominal Pain
Nausea
Ankle Swelling
Oedema
Fatigue
Contraindications: Amtorque 5 is contraindicated in patients with a known allergy to dihydropyridine derivatives, amlodipine, or excipients, in patients with hypotension, shock, high grade aortic stenosis and haemodynamically unstable heart failure after acute myocardial infarction.
Drug Interactions: Amtorque 5 can cause drug interaction with following drugs:
Protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem
CYP3A4 inducers (e.g. Rifampicin, hypericum perforatum)
CYP3A4 Inhibitors(e.g. Erythromycin, diltiazem, & verapamil)
Dantrolene (infusion)
Tacrolimus, Sirolimus, Temsirolimus, and Everolimus
Simvastatin
