Product Description
Description: Amtorque AT Tablets contain Amlodipine a calcium channel blocker, selective calcium channel blockers with mainly vascular effects and Atenolol, a beta-blocker which is beta1-selective, acts preferentially on beta1-adrenergic receptors in the heart.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition:
Each uncoated tablet contains:
Amlodipine Besilate IP
Eq. to Amlodipine 5 mg
Atenolol IP 50 mg
Excipients q.s.
Mechanism of Action: The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which amlodipine relieves angina has not been fully determined but amlodipine reduces total ischemic burden by the following two actions. Amlodipine dilates peripheral arterioles and thus, reduces the total peripheral resistance (afterload) against which the heart works. The mechanism of action of amlodipine also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal’s or variant angina). Atenolol reduces cardiac rate and contractility which makes it effective in eliminating or reducing the symptoms of patients with angina.
Indications: Amtorque AT Tablet is indicated for the treatment of mild to moderate hypertension
and all grades of angina, unresponsive to Atenolol or Amlodipine monotherapy.
Dosage: As directed by the physician.
Storage: Store protected from light & moisture, at a temperature not exceeding 30°C.
Presentation: 20 x 10
Side effects:
Somnolence, Dizziness, Headache
Visual Disturbance
Palpitations, Flushing, Dyspnoea
Abdominal Pain, Nausea, Dyspepsia, Altered Bowel Habits
Ankle Swelling, Muscle Cramps
Fatigue, Asthenia
Contraindications: Amlodipine is contraindicated in patients with hypersensitivity to dihydropyridine derivatives, amlodipine, atenolol or to any of the excipients or to any of the excipients, Severe hypotension, Shock (including cardiogenic shock), Obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis)., Haemodynamically unstable heart failure after acute myocardial infarction, uncontrolled heart failure, sick sinus syndrome, second-or third-degree heart block, untreated phaeochromocytoma, metabolic acidosis, bradycardia, hypotension and severe peripheral arterial circulatory disturbances.
Drug Interactions: Amtorque AT Tablets can cause drug interaction with following drugs:
Protease Inhibitors,
Azole Antifungals
Macrolides Like Erythromycin or Clarithromycin
Verapamil
Diltiazem
Rifampicin
Dantrolene
Tacrolimus
Cyclosporine
Simvastatin
Nifedipine
Adrenaline
Insulin and Oral Antidiabetic Drugs
Ibuprofen and Indomethacin
Anaesthetic Agents
