Description: Ceftorque S 375 is sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration, which is used to treat infections caused by various gram-positive and negative bacteria.
Dosage Form: Dry Injection
Route of Administration: Intravenous & Intramuscular
Composition: Each vial contains: Ceftriaxone Sodium (Sterile) IP Eq. to Anhydrous Ceftriaxone 250 mg Sulbactam Sodium (Sterile) IP Eq. to Anhydrous Sulbactam 125 mg
Mechanism of Action. Ceftriaxone acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) inside the bacterial cell wall, blocking the final transpeptidation step of peptidoglycan synthesis, which is essential for cell wall strength and rigidity. This results in weakening of the cell wall, leading to cell lysis and bacterial death. Sulbactam, by irreversibly binding to the beta-lactamases produced by the common gram-positive or negative bacteria, protects the beta-lactam ring of ceftriaxone, and conserves the bactericidal activity of Ceftriaxone.
Indications: Ceftorque S 375 is used to treat UTI, respiratory tract infections, bacteremia, sepsis, meningitis, abdominal infections, infections of the bones, joints, soft tissue, skin and wounds, renal and urinary tract infections, and ear, nose and throat infections, Acute Bacterial Otitis Media and uncomplicated gonorrhea.
Dosage: As directed by the physician.
Side effects: Abnormalities with your white blood cells (such as a decrease of leucocytes and an increase of eosinophils) and platelets (decrease of thrombocytes). Loose stools, Pruritus, Diarrhoea, Nausea, Vomiting
Contraindications: Ceftorque S 375 is contraindicated in Patients with known or suspected hypersensitivity to the drug or any of the excipients, during pregnancy and lactation, in patients with severe hepatic failure or renal impairment.
Drug Interactions: Ceftorque S 375 can cause drug interactions with the following drugs: Vancomycin, Oral anticoagulants, Fluconazole, Interaction with Calcium-containing Products and Chloramphenicol.
Storage: Store at a temperature not exceeding 25 °C. Protect from sunlight, heat and moisture.
Presentation: 375mg Glass Vial