Description: Flukonazole-150 tablet is a systemic antifungal medication that works by inhibiting the synthesis of ergosterol, and it is used to treat a variety of fungal infections, including candidiasis.
Dosage Form: Tablet
Route of Administration: Oral
Composition: Each uncoated tablet contains:
Fluconazole I.P. 150mg
Excipients q.s.
Mechanism of Action: Fluconazole exerts its antifungal effects by inhibiting the enzyme lanosterol 14α-demethylase, which is essential for the conversion of lanosterol to ergosterol—a crucial component of fungal cell membranes. By blocking this step in the ergosterol biosynthesis pathway, fluconazole disrupts the integrity of the fungal cell membrane, leading to increased permeability and impaired function. This interference with membrane synthesis ultimately results in the inhibition of fungal growth and replication.
Indications: Flukonazole-150 tablet is used to treat fungal infections of the mouth, throat, vagina, and other parts of the body, including fingernails and toenails.
Dosage: As directed by the physician.
Side effects: Drowsiness, Nausea, Headache, Heartburn, Upset stomach.
Contraindications: Flukonazole-150 is contraindicated in patients who have shown hypersensitivity to fluconazole or to any of its excipients. Co-administered of Cisapride or Terfenadine is contraindicated.
Drug Interactions: Flukonazole-150 can interact with other drugs, potentially affecting their efficacy or increasing the risk of side effects. Here are some notable drug interactions with Flukonazole-150 – Oral hypoglycemic, Phenytoin, Cyclosporine, Rifampin, Theophylline, Terfenadine, Cisapride, Rifabutin, Astemizole.
Storage: Store in a cool, dry place.
Presentation: 1 x 1 tablet