DESCRIPTION: Fungizole-V Cream contains Metronidazole and Clotrimazole. It is used for the treatment of mixed bacterial and fungal infections. Clotrimazole acts as an antifungal agent, while Metronidazole provides antibacterial and antiprotozoal action, together offering broad-spectrum relief from itching, irritation, and discharge associated with vaginal infections.
COMPOSITION:
|
Metronidazole |
B.P. |
10% w/w |
|
Clotrimazole |
B.P. |
2% w/w |
|
Methylparaben |
I.P. |
0.2% w/w |
|
I.P. |
0.1% w/w |
MECHANISM OF ACTION: Clotrimazole acts by inhibiting the fungal cytochrome P450 enzyme Lanosterol 14-demethylase, and thus impairs ergosterol synthesis, leading to a cascade of membrane abnormalities in the fungus. Metronidazole is reduced by bacterial nitroreductase to an unstable intermediate, which interacts with DNA effectively, preventing further replication.
INDICATIONS: Vaginitis due to fungi, mainly Candida and/or Trichomonas. Superinfection with bacteria sensitive to gram streptococci/staphylococci and gram-negative Bacteroides.
SIDE EFFECTS: Burning, stinging, redness, swelling, fever, irritation.
CONTRAINDICATIONS: Hypersensitivity to any of the ingredients of this medicine.
PRECAUTIONS & WARNINGS: Metronidazole is carcinogenic in mice and rats. Unnecessary use of the drug should therefore be avoided.
DOSAGE: As prescribed by the physician.
PRESENTATION: 45g tube
FOR VAGINAL USE ONLY