DESCRIPTION: Ketomac Tablets contain Ketoconazole, an effective, broad-spectrum, systemic antifungal agent and used to treat various fungal infections.
DOSAGE FORM: Tablets
ROUTE OF ADMINISTRATION: Oral
COMPOSITION: Each uncoated tablet contains:
|
Ketoconazole |
I.P. |
200 mg |
MECHANISM OF ACTION: Ketoconazole blocks the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14α-demethylase responsible for the conversion of lanosterol to ergosterol in the fungal cell membrane. This results in an accumulation of methylated sterol precursors and a depletion of ergosterol within the cell membrane thus weakening the structure and function of the fungal cell membrane.
INDICATIONS: Ketomac Tablets are indicated for the treatment of systemic fungal infections in patients who have failed or who are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
CONTRAINDICATIONS: Substrates such as dofetilide, quinidine, cisapride and pimozide is contraindicated with ketoconazole Tablets.
SIDE EFFECTS: Mild nausea, Vomiting, or Stomach pain; Mild itching or Skin rash; Headache; Dizziness.
DOSAGE: As directed by the physician.
STORAGE: Store in a cool & dry place. Protect from light.
PRESENTATION: 100x10x10 Tablets
BARCODE: 0118906044107813, 0108906044107816, 0128906044107810