KOFF GO PLUS TABLETS

Ambroxol Hydrochloride is the metabolite of bromhexine and a mucolytic agent. Ambroxol acts as secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Cetirizine is a second-generation antihistamine used in the treatment of allergies, hay fever, angioedema, and urticaria. It is a major metabolite of hydroxyzine and a racemic selective H1 receptor inverse agonist.

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Product Description

DESCRIPTION:
Ambroxol Hydrochloride is the metabolite of bromhexine and a mucolytic agent. Ambroxol acts as secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Cetirizine is a second-generation antihistamine used in the treatment of allergies, hay fever, angioedema, and urticaria. It is a major metabolite of hydroxyzine and a racemic selective H1 receptor inverse agonist.

PACKING:
60x20x10 tablets

COMPOSITION:
Each film-coated tablet contains:

Cetirizine Hydrochloride
I.P.
5 mg
Ambroxol Hydrochloride
I.P.
60 mg

MECHANISM OF ACTION:
Ambroxol facilitates mucociliary clearance by intensifying the motion of the cilia present on the ciliated respiratory epithelium. Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. It crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines.

INDICATIONS:
Seasonal/allergic rhinitis, nasal discomfort, body ache, stubborn cough.

CONTRAINDICATIONS:
Hypersensitivity to any ingredient of the product.

WARNING:
Do not exceed recommended dosage.

DOSAGE:
As directed by the physician.

STORAGE:
Store in a cool & dry place. Protect from light.

PRESENTATION:
20×10 tablets in a cardboard carton



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