1. Description: Torque’s Orthomac-MR tablet combines diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), with paracetamol for pain relief and chlorzoxazone, a muscle relaxant, to effectively manage pain, inflammation, and muscle spasms.
2. Pharmaceutical Dosage Form: Tablet
3. Route of Administration: Oral
4. Composition: Each uncoated tablet contains:
Diclofenac Sodium I.P. 50mg
Paracetamol I.P. 325mg
Chlorzoxazone U.S.P. 250mg
Excipients q.s.
5. Mechanism of Action: Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and anti-pyretic activity. It’s primarily inhibits the enzyme cyclooxygenase (COX). COX is involved in the synthesis of prostaglandins, which are substances in the body that mediate inflammation, pain, and fever. By inhibiting COX, diclofenac sodium reduces the production of prostaglandins, thereby mitigating inflammation, relieving pain, and lowering fever. This anti-inflammatory and analgesic effect makes diclofenac sodium commonly used in the treatment of conditions such as arthritis, musculoskeletal pain, and inflammatory disorders. Paracetamol is an analgesic and antipyretic drug that is used to relieve mild-to-moderate pain and fever. Chlorzoxazone is an analgesic belonging to the class skeletal muscle relaxant. It inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow reacting substance of anaphylaxis (SRS-A), mediator of type I allergic reactions. It also may reduce the release of inflammatory leukotrienes. It may act by inhibiting calcium and potassium influx which would lead to neuronal inhibition and muscle relaxation.
6. Indications: Torque’s Orthomac-MR tablet is used in the treatment of pain due to muscle spasm.
7. Dosage: As directed by the physician.
8. Storage: Store in a dry place, protect from sunlight.
9. Presentation: 1 x 10 tablets.
10. Side effects:
Drowsiness
Constipation
Diarrhea
Stomach upset
11. Contraindications: Torque’s Orthomac-MR tablet is contraindicated in patients with a history of hypersensitivity to the drug or any excipients from the dosage form.
12. Drug interactions: Torque’s Orthomac-MR tablet can interact with other drugs. Here are some notable drug interactions with this medication:
Naproxen
Aspirin
Tramadol
Oxycodone
Rivaroxaban
Warfarin
Cimetidine
Prednisone
