Product Description
Description: Torque’s Glimtor M2 Tablets contains Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose and Glimepiride, a sulphonylurea antihyperglycaemic agent acts mainly by stimulating insulin release from pancreatic beta cells.
Pharmaceutical Dosage Form: Tablet
Route of Administration: Oral
Composition:
Each uncoated bilayered tablet contains:
Metformin Hydrochloride IP 500 mg
(As Prolonged Release)
Glimepiride IP 1 mg
Excipients q.s.
Mechanism of Action: Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta-cells. It binds to the sulphonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin.
Indications: Torque’s Glimtor M2 is indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and single agent does not result in adequate glycemic control.
Dosage: As directed by the physician.
Storage: Store at a temperature not exceeding 30°C, protected from light & moisture.
Presentation: 15 x 2 x 15
Side effects: The following adverse reactions may occur:
Lactic Acidosis
Taste Disturbance
Nausea
Vomiting
Diarrhoea
Abdominal Pain
Loss of Appetite
Contraindications:
Torque’s Glimtor M2 is contraindicated in patients with:
Known hypersensitivity to metformin, glimepiride or any of the components of this product.
Severe renal impairment
Acute or chronic metabolic acidosis, including diabetic ketoacidosis and lactic acidosis
Diabetic pre-coma
An allergic reaction to sulphonamide derivatives may develop an allergic reaction
Hepatic insufficiency, acute alcohol intoxication, alcoholism
Insulin dependent diabetes
Drug Interactions:
Alcohol
NSAIDs
ACE Inhibitors
Angiotensin II Receptor Antagonists
Diuretics
Verapamil
Rifampicin
Cimetidine, Dolutegravir, Ranolazine, Trimethoprime,
Isavuconazole, Fluconazole
Vandetanib, Crizotinib, Olaparib
Thyroid Stimulating Agents, Glucocorticoids
Anabolic Steroids and Male Sex Hormones
