DESCRIPTION:
Trixone Plus Injection is a combination of a beta-lactam antibiotic- Ceftriaxone with an inhibitor of beta lactamase-Sulbactam sodium, giving a highly powerful antibacterial formulation. ?Ceftriaxone is a third-generation cephalosporin antibiotic, Sulbactam sodium is a derivative of the basic penicillin nucleus.
PACKING:
12x12x1.5g vial
COMPOSITION:
Each vial contains:
Part I
Ceftriaxone Sodium Sterile
U.S.P
1g
equi. to Ceftriaxone
Salbactum Sodium
U.S.P
500mg
equi. to Salbactum
Part II
Water for Injection
B.P.
10ml
MECHANISM OF ACTION:
Ceftriaxone inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to the specific PBPs located inside the bacterial cell wall. Ceftriaxone interferes with PBP-mediated cell wall synthesis leading to cell lysis and death. Sulbactam, by irreversibly binding to the beta-lactamases produced by the bacteria protects the beta-lactam ring of ceftriaxone and conserves the activity. The combination helps extend its utility in the treatment of a broad range of infections caused by organisms resistant to the antibiotic alone.
INDICATIONS:
Renal and urinary tract infections, skin and soft tissue infections, infections in a dialysis unit.
CONTRAINDICATIONS:
Contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Hypersensitivity to penicillin may predispose the patient to the possibility of allergic cross-reactions.
SIDE EFFECTS:
Diarrhoea, nausea & vomiting, headache, dizziness, increase in serum creatinine.
DOSAGE:
As prescribed by the physician.
STORAGE:
Store in a single-dose container in the frozen state.
FOR IM/IV USE ONLY
PRESENTATION:
1.5gm vial
BARCODE:
